Synthesis of 2,3,4-Trisubstituted Chromans Via Nucleophilic Addition of N-, C-, and SNucleophiles to 3-Nitro-2-Trihalomethyl-2H-Chromenes. Stereochemical and Conformational Preferences

Author(s): V. Y. Korotaev, V. Y. Sosnovskikh, I. B. Kutyashev, M. I. Kodess.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 7 , 2005

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Abstract:

Reactions of N-, C-, and S-nucleophiles with 3-nitro-2-trifluoro(or trichloro)methyl-2H-chromenes proceeded via nucleophilic addition at the double bond to give 2,3,4-trisubstituted chromans in good to moderate yields. Stereochemical and conformational preferences of 2,3,4-trisubstituted chromans were studied.

Keywords: nitro- h-chromenes, s-nucleophiles, nucleophilic addition, trisubstituted chromans

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Page: [616 - 620]
Pages: 5
DOI: 10.2174/157017805774297000
Price: $65

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