Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer

Author(s): Xianghong Wang, Y. C. Wong, Dong-Yan Jin.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 2 , 2005

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Abstract:

The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.

Keywords: eukaryotic cells, dna replication, chromosome, cell cycle checkpoints, kinetochores

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [97 - 104]
Pages: 8
DOI: 10.2174/1570180053175098
Price: $58