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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer

Author(s): Xianghong Wang, Y. C. Wong and Dong-Yan Jin

Volume 2, Issue 2, 2005

Page: [97 - 104] Pages: 8

DOI: 10.2174/1570180053175098

Price: $65

Abstract

The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.

Keywords: eukaryotic cells, dna replication, chromosome, cell cycle checkpoints, kinetochores


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