Abstract
The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.
Keywords: eukaryotic cells, dna replication, chromosome, cell cycle checkpoints, kinetochores
Letters in Drug Design & Discovery
Title: Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer
Volume: 2 Issue: 2
Author(s): Xianghong Wang, Y. C. Wong and Dong-Yan Jin
Affiliation:
Keywords: eukaryotic cells, dna replication, chromosome, cell cycle checkpoints, kinetochores
Abstract: The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.
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Cite this article as:
Wang Xianghong, Wong C. Y. and Jin Dong-Yan, Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer, Letters in Drug Design & Discovery 2005; 2 (2) . https://dx.doi.org/10.2174/1570180053175098
DOI https://dx.doi.org/10.2174/1570180053175098 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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