Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer
Y. C. Wong,
The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.
Keywords: eukaryotic cells, dna replication, chromosome, cell cycle checkpoints, kinetochores
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