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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor

Author(s): Maria E. Ariza, Irene Pedersen and M. V. Williams

Volume 2, Issue 2, 2005

Page: [92 - 96] Pages: 5

DOI: 10.2174/1570180053175179

Price: $65

Abstract

We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.

Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma


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