Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor

Author(s): Maria E. Ariza, Irene Pedersen, M. V. Williams.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 2 , 2005

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Abstract:

We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.

Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [92 - 96]
Pages: 5
DOI: 10.2174/1570180053175179
Price: $58