Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor
Maria E. Ariza,
M. V. Williams.
We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.
Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma
Rights & PermissionsPrintExport