Introduction of a Benzoquinone Pharmacophore on a Labdane Platform

Author(s): J. Aslaoui, C. Morin.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 6 , 2005

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Abstract:

The allylic alcohol of the side-chain of larixol was converted into an exo 1,3-diene through trifluoroacetylation followed by palladium-catalyzed elimination; this allowed the introduction of a benzoquinone pharmacophore on this labdane platform in one-pot from allylic trifluoroacetates.

Keywords: diene, allylic trifluoroacetate, larixol, quinone, labdane

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Article Details

VOLUME: 2
ISSUE: 6
Year: 2005
Page: [515 - 517]
Pages: 3
DOI: 10.2174/1570178054640705
Price: $65

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