QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments

Author(s): T. L. Wilson, P. L. Jackson, C. D. Hanson, Z. Xue, N. D. Eddington, K. R. Scott.

Journal Name: Medicinal Chemistry

Volume 1 , Issue 4 , 2005

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Abstract:

The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative structure-activity relationship (QSAR) correlation model for prediction of activity for the anticonvulsant enaminones. Molecular modeling was performed to determine the molecular confluence of the Unverferth model (J. Med. Chem. 1998, 41, 63-73) to the enaminones. Conclusions related to the sodium channel model were assessed.

Keywords: epilepsy, sodium channel, anticonvulsants, molecular modeling, regression analysis

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2005
Page: [371 - 381]
Pages: 11
DOI: 10.2174/1573406054368710
Price: $58

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