New non-peptidic Inhibitors of Papain Derived from Etacrynic Acid

Author(s): U. Kaeppler, T. Schirmeister.

Journal Name: Medicinal Chemistry

Volume 1 , Issue 4 , 2005

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Cysteine proteases are connected to various viral and parasitic infections, as well as to other severe diseases like arthritis, stroke and cancer. Due to its α,β-unsaturated carbonyl moiety etacrynic acid, a well known diuretic, can inhibit cysteine proteases in a Michael-type reaction by reaction with the nucleophilic cysteine residue of the active site. For first structure-activity-relationship studies modifications at various positions of the etacrynic acid structure have been investigated concerning inhibition potency against the CAC1 protease papain: length of the side chain, substitution pattern of the aromatic ring as well as influence and necessity of acidic groups, esters or amides. Additionally, the effect of the aromatic ring was evaluated by replacement with a cyclohexyl moiety.

Keywords: cysteine protease inhibitor, michael addition, papain, etacrynic acid

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Article Details

Year: 2005
Page: [361 - 370]
Pages: 10
DOI: 10.2174/1573406054368701
Price: $65

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