Abstract
The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Mini-Reviews in Medicinal Chemistry
Title: Non-Steroidal Progesterone Receptor Specific Ligands
Volume: 5 Issue: 8
Author(s): G. F. Allan and Z. Sui
Affiliation:
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Abstract: The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
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Cite this article as:
Allan F. G. and Sui Z., Non-Steroidal Progesterone Receptor Specific Ligands, Mini-Reviews in Medicinal Chemistry 2005; 5 (8) . https://dx.doi.org/10.2174/1389557054553794
DOI https://dx.doi.org/10.2174/1389557054553794 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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