Non-Steroidal Progesterone Receptor Specific Ligands

Author(s): G. F. Allan, Z. Sui.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 8 , 2005

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Abstract:

The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.

Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone

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Article Details

VOLUME: 5
ISSUE: 8
Year: 2005
Page: [701 - 708]
Pages: 8
DOI: 10.2174/1389557054553794
Price: $58

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