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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Advances in the Synthesis of C-oligosaccharides

Author(s): Xuejun Yuan and Robert J. Linhardt

Volume 5, Issue 14, 2005

Page: [1393 - 1430] Pages: 38

DOI: 10.2174/156802605774643033

Price: $65

Abstract

This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.

Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal


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