Cholesteryl Ester Transfer Protein: Pharmacological Inhibition for the Modulation of Plasma Cholesterol Levels and Promising Target for the Prevention of Atherosclerosis.

Author(s): Roger B. Ruggeri.

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 3 , 2005

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Abstract:

Cholesteryl ester transfer protein (CETP) facilitates the exchange of neutral lipids (such as cholesteryl esters and triglycerides) between anti-atherogenic HDL particles and pro-atherogenic VLDL and LDL particles in human plasma. Individuals possessing a genetic deficiency for CETP have higher HDL cholesterol and lower LDL cholesterol and may have a reduced risk for developing cardiovascular disease. Small molecule inhibitors of CETP are being developed that would appear to provide a beneficial change in lipoprotein profile. However, randomized clinical trials are ultimately required to determine whether CETP inhibition will afford a reduction in cardiovascular events.

Keywords: low-density lipoprotein cholesterol (ldl-c), coronary heart disease (chd), reverse cholesterol transport(rct), inflammatory processes, vascular endothelial cells, glycopeptide, phospholipids

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2005
Page: [257 - 264]
Pages: 8
DOI: 10.2174/1568026053544506
Price: $58