Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †
Venugopal Rao Veeramaneni,
Shaikh Abdul Rajjak,
Vidya B. Lohray,
Seshagiri Rao Casturi,
Koteswar Rao Yeleswarapu.
A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3- dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. Structure Activity Relationship study within the series are discussed.
Keywords: diarylpyrazoles, cox, &, cox inhibition, structure activity relationship (sar) study
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