Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †

Author(s): Manojit Pal, Venugopal Rao Veeramaneni, Sanjeev Kumar, Akhila Vangoori, Ramesh Mullangi, Parimal Misra, Shaikh Abdul Rajjak, Vidya B. Lohray, Seshagiri Rao Casturi, Koteswar Rao Yeleswarapu.


A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3- dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. Structure Activity Relationship study within the series are discussed.

Keywords: diarylpyrazoles, cox, &, cox inhibition, structure activity relationship (sar) study

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Article Details

Year: 2005
Page: [329 - 340]
Pages: 12
DOI: 10.2174/1570180054038459
Price: $58