Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

Author(s): D. Reglodi, A. Tamas, A. Somogyvari-Vigh.

Abstract:

The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.

Keywords: pacap, neurodegeneration, neuroprotection, parkinson, huntington

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [311 - 315]
Pages: 5
DOI: 10.2174/1570180054038440
Price: $58