The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A2 (PLA2) [E.C. 22.214.171.124] enzyme inhibition. The in vitro PLA2 enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA2 inhibitors and can also be used as antiinflammatory drugs.
Keywords: phospholipase, anti-inflammatory, azetidin-one derivatives
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