Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

Author(s): Mayur C. Yerigeri, Satish Kumar Murari, Salahuddin Mohammed, Shanta Kumar Sugur Math, Kuntebommanahalli N. Thimmaiah, Bannikuppe Sannanaik Vishwanath.

Abstract:

The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A2 (PLA2) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA2 enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA2 inhibitors and can also be used as antiinflammatory drugs.

Keywords: phospholipase, anti-inflammatory, azetidin-one derivatives

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [307 - 310]
Pages: 4
DOI: 10.2174/1570180054038404
Price: $58