Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Author(s): Claudio Olea-Azar, Carolina Rigol, Fernando Mendizabal, Hugo Cerecetto, Rossanna Di Maio, Mercedes Gonzalez, Williams Porcal, Antonio Morello, Yolanda Repetto, Juan Diego Maya.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 4 , 2005

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In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction processes. Effects on the parasitic respiration were studied.

Keywords: oxadiazole n-oxide, trypanosoma cruzi, cyclic voltammetry, esr spectroscopy, cellular respiration

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Article Details

Year: 2005
Page: [294 - 301]
Pages: 8
DOI: 10.2174/1570180054038341
Price: $58

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