Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

Author(s): Laura Cipolla , Cristina Redaelli , Francesco Nicotra .

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 4 , 2005

Become EABM
Become Reviewer


A bicyclic spiro analogue of D-proline was synthesized from perbenzylated methyl D-fructoside. The synthetic steps required first a three carbon chain elongation at the anomeric position by C-glycosylation, secondly the introduction of the amino function at C-1, and finally the cyclization to the pyrrolidine ring and introduction of the carboxylic group.

Keywords: d-proline, fructose, amino acid analogue, c-glycosides

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2005
Page: [291 - 293]
Pages: 3
DOI: 10.2174/1570180054038369
Price: $58

Article Metrics

PDF: 2