Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

Author(s): Laura Cipolla, Cristina Redaelli, Francesco Nicotra.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 4 , 2005

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Abstract:

A bicyclic spiro analogue of D-proline was synthesized from perbenzylated methyl D-fructoside. The synthetic steps required first a three carbon chain elongation at the anomeric position by C-glycosylation, secondly the introduction of the amino function at C-1, and finally the cyclization to the pyrrolidine ring and introduction of the carboxylic group.

Keywords: d-proline, fructose, amino acid analogue, c-glycosides

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [291 - 293]
Pages: 3
DOI: 10.2174/1570180054038369
Price: $58

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