A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Author(s): S. P. Gupta , Anitha Paleti , S. B. Mekapati , A. N. Nagappa , S. Kumaran .

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 4 , 2005

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A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

Keywords: channel blockers, qsar, connectivity index

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Article Details

Year: 2005
Page: [287 - 290]
Pages: 4
DOI: 10.2174/1570180054038422
Price: $58

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