Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Author(s): S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa, S. Kumaran.

Abstract:

A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

Keywords: channel blockers, qsar, connectivity index

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [287 - 290]
Pages: 4
DOI: 10.2174/1570180054038422
Price: $58