A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Author(s): John M. Ringman , Sally A. Frautschy , Gregory M. Cole , Donna L. Masterman , Jeffrey L. Cummings .

Journal Name: Current Alzheimer Research

Volume 2 , Issue 2 , 2005

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There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimers disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

Keywords: curcuma longa, liver disease, anti-oxidant, cytokines, inflammation, (nsaid), cholesterol, fibrils, pharmacokinetic, microglia

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Article Details

Year: 2005
Page: [131 - 136]
Pages: 6
DOI: 10.2174/1567205053585882
Price: $58

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