A Potential Role of the Curry Spice Curcumin in Alzheimers Disease
John M. Ringman, Sally A. Frautschy, Gregory M. Cole, Donna L. Masterman and Jeffrey L. Cummings
Affiliation: UCLA Dept. of Neurology, Alzheimer's Disease Research Center, 710 Westwood Plaza, Suite 2-238,Los Angeles, CA 90095-1769, USA.
Keywords: curcuma longa, liver disease, anti-oxidant, cytokines, inflammation, (nsaid), cholesterol, fibrils, pharmacokinetic, microglia
There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimers disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.
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