Login

Journal Image
Current Alzheimer Research
ISSN (Print): 1567-2050
ISSN (Online): 1875-5828
VOLUME: 2
ISSUE: 2
DOI: 10.2174/1567205053585954      Price:  $58









C-1073 (Mifepristone) in the Adjunctive Treatment of Alzheimers Disease

img
Author(s): Charles DeBattista and Joseph Belanoff
Pages 125-129 (5)
Abstract:
Alzheimers disease is frequently associated with abnormalities in the hypothalamic pituitary adrenal axis. Elevated cortisol levels in Alzheimers disease may in turn be associated with a more rapid progression of the illness. In addition, elevated cortisol levels may directly contribute to cognitive deficits in Alzheimers disease. Mifepristone is a potent antagonist of the glucocorticoid receptor and blocks the central actions of cortisol. The purpose of this study is to determine the effects of glucocorticoid receptor blockade with mifepristone on cognition in Alzheimers disease.
Keywords:
glucocorticoid II receptor, hypothalamic pituitary adrenal (hpa), psychotic major depression (pmd), hippocampus, progesterone, transcription, dna, cushing, ’, s disease, hypercortisolemia, bipolar affective disorder
Affiliation:
Corcept Therapeutics, 275 Middlefield Road, Menlo Park, California 94025, USA.