Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives

Author(s): Ivan N. Junior , Maria C. S. Lourenco , Maria das Gracas M. O. Henriques , Barbara Ferreira , Thatyana R. A. Vasconcelos , Monica A. Peralta , Pedro S. M. de Oliveira , Solange M. S. V. Wardell , Marcus V. N. de Souza .

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 7 , 2005

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Abstract:

A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.

Keywords: Isoniazid, tuberculosis, antimycobacterial activity

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Page: [563 - 566]
Pages: 4
DOI: 10.2174/157018005774479131
Price: $58

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