Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives
Ivan N. Junior,
Maria C. S. Lourenco,
Maria das Gracas M. O. Henriques,
Thatyana R. A. Vasconcelos,
Monica A. Peralta,
Pedro S. M. de Oliveira,
Solange M. S. V. Wardell,
Marcus V. N. de Souza.
A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
Keywords: Isoniazid, tuberculosis, antimycobacterial activity
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