L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?
L-dopa is the most effective drug in the symptomatic management of PD and extends the life span of PD patients.The question whether L-dopa is neurotoxic remains however unresolved. In recent years, increased Homocysteine (Hcy) levels have been observed in L-dopa treated Parkinsons disease (PD) patients, resulting from L-dopa O-methylation by the enzyme catechol-O-methyltransferase. This review summarizes current evidences supporting the possible role of Hcy as mediator of L-dopa toxicity mainly on dopaminergic neurons.
Keywords: Homocysteine, Levodopa, Parkinson's disease, toxicity, dopaminergic neurons
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