Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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A Review of the Regulatory Role of Nicotinamide on Pro- and Anti-apoptotic Proteins in Neuronal Cells

Author(s): S. K. Mukherjee, M. Sonee, J. D. Adams Jr.

Abstract:

Numerous studies have shown that nicotinamide can prevent cell death via both necrosis and apoptosis. DNA fragmentation, NAD, poly(ADP-ribose) polymerase, apoptosis inducing factors, tumor necrosis factors, p53, caspases, inhibitor of apoptosis proteins and other factors are important in the action of nicotinamide. In this review, the regulatory effect of nicotinamide on individual pro- and anti-apoptotic proteins in neuronal cells have been delineated with a view to present a central molecular mechanism by which nicotinamide prevents apoptosis in the brain.

Keywords: Apoptosis, caspase, inhibitor of apoptosis proteins (IAPs), poly (ADP-ribose) polymerase (PARP), oxidative stress

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Page: [551 - 557]
Pages: 7
DOI: 10.2174/157018005774479177
Price: $58