Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Evaluation of Some 16-Benzylidene Substituted 3,17- Dioximino Androstene Derivatives as Anticancer Agents

Author(s): Sonal Dubey, Poonam Piplani and Dharam P. Jindal

Volume 2, Issue 7, 2005

Page: [537 - 545] Pages: 9

DOI: 10.2174/157018005774479186

Price: $65

Abstract

The synthesis of some steroidal dioximes (22-29) and their in vitro antineoplastic activity are described in this report. The oximino functionality was incorporated at position 3 and 17 of the 16- benzylidene substituted steroidal nucleus to study the importance of dioximino moiety on anticancer activity. The synthesized compounds were screened for their in vitro antitumor activity against the cell panel consisting of three lines (breast, brain and lungs) at NCI, Bethesda, USA. After selective analysis, compounds 23-28 indicated statistically significant antineoplastic activity for further studies.

Keywords: Steroidal, oxime, anticancer, dehydroepiandrosterone


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy