Abstract
A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.
Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors
Letters in Drug Design & Discovery
Title: Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives
Volume: 2 Issue: 7
Author(s): Jose M. Padron, David Tejedor, Alicia Santos-Exposito, Fernando Garcia-Tellado, Jesus Villar and Victor S. Martin
Affiliation:
Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors
Abstract: A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.
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Cite this article as:
Padron M. Jose, Tejedor David, Santos-Exposito Alicia, Garcia-Tellado Fernando, Villar Jesus and Martin S. Victor, Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479122
DOI https://dx.doi.org/10.2174/157018005774479122 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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