Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives

Author(s): Jose M. Padron, David Tejedor, Alicia Santos-Exposito, Fernando Garcia-Tellado, Jesus Villar, Victor S. Martin.

Abstract:

A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.

Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Page: [529 - 532]
Pages: 4
DOI: 10.2174/157018005774479122
Price: $58