Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives
Jose M. Padron,
Victor S. Martin.
A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.
Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors
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