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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships

Author(s): Sarah R. Dennison, James Wallace, Frederick Harris and David A. Phoenix

Volume 12, Issue 1, 2005

Page: [31 - 39] Pages: 9

DOI: 10.2174/0929866053406084

Price: $65

Abstract

To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

Keywords: antimicrobial peptides, amphiphilicity, microbial membranes


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