Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships
Sarah R. Dennison, James Wallace, Frederick Harris and David A. Phoenix
Pages 31-39 (9)
To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
antimicrobial peptides, amphiphilicity, microbial membranes
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