Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships
Sarah R. Dennison,
David A. Phoenix.
To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
Keywords: antimicrobial peptides, amphiphilicity, microbial membranes
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