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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 12
ISSUE: 1
DOI: 10.2174/0929866053406084









Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships

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Author(s): Sarah R. Dennison, James Wallace, Frederick Harris and David A. Phoenix
Pages 31-39 (9)
Abstract:
To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
Keywords:
antimicrobial peptides, amphiphilicity, microbial membranes
Affiliation:
Deans Office, Faculty of Science, University of Central Lancashire, Preston, PR1 2HE, UK.