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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 12
ISSUE: 1
DOI: 10.2174/0929866053406039









Are Oblique Orientated α-Helices Used by Antimicrobial Peptides for Membrane Invasion?

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Author(s): Sarah R. Dennison, Frederick Harris and David A. Phoenix
Pages 27-29 (3)
Abstract:
Oblique orientated α-helices are highly specialised protein structural elements that penetrate membranes at a shallow angle and are used to promote membrane destabilisation by a number of protein classes. Here, the use of extended hydrophobic moment methodology shows that the amphibian extrudates, aurein 1.2 and citropin 1.1, may use oblique orientated α-helices in their antimicrobial action and that such use may be shared by other antimicrobial peptides. This appears to be the first systematic analysis of these peptides for the possession of oblique orientated a-helical structure.
Keywords:
peptides, hydrophobicity, membrane destabilisation, haemolysis, non-bilayer lipid structures
Affiliation:
Deans Office, Faculty of Science, University of Central Lancashire, Preston, PR1 2HE, UK.