Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Insect Antimicrobial Peptides: Structures, Properties and Gene Regulation

Author(s): Philippe Bulet and Reto Stocklin

Affiliation: Atheris Laboratories, Case Postale 314, CH-1233 Bernex, Geneva, Switzerland.

Abstract:

Antimicrobial peptides (AMPs) are part of the armament that insects have developed to fight off pathogens. Insect AMPs are typically cationic and often made of less than 100 amino acid residues. Although their structures are diverse, most of the AMPs can be assigned to a limited number of families. The most common structures are represented by peptides assuming a α-helical conformation in organic solutions or disulfide-stabilized β-sheets with or without α- helical domains present. The diverse activity spectrum of these peptides may indicate different modes of action. Genetic analysis in the Drosophila model evidenced that multiple signal transduction pathways are activating the genes coding AMPs.

Keywords: antimicrobial peptides, insect immunity, microbial infection, cecropin, defensin, proline-rich, innate defense, cationic peptide

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Article Details

VOLUME: 12
ISSUE: 1
Page: [3 - 11]
Pages: 9
DOI: 10.2174/0929866053406011