Current Protein & Peptide Science

Ben M. Dunn  
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245
USA

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Defensins - Non-antibiotic Use for Vaccine Development

Author(s): Arya Biragyn

Affiliation: Laboratory of Immunology,Gerontology Research Center, National Institute on Aging, National Institutes of Health, Rm 4B09, 5600 Nathan Shock Drive, Box 21,Baltimore, Maryland 21224, USA.

Keywords: antimicrobial peptides, dendritic cells, vaccine carrier

Abstract:

Vaccines should elicit protective and long lasting immune memory, which depends on well choreographed responses between innate and acquired immunity. Defensins are small host defense peptides of innate immunity hitherto reported to have antimicrobial activity, which also orchestrate chemotaxis and activation of effector immune cells, including immature dendritic cells. This review analyzes the biological meaning of the immunomodulatory and immunoenhancing features of defensins and their use for the development of novel vaccines to combat cancer and clinically relevant diseases.

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Article Details

VOLUME: 6
ISSUE: 1
Page: [53 - 60]
Pages: 8
DOI: 10.2174/1389203053027601