Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

Author(s): L. M. Ritter, T. Arakawa, A. F.X. Goldberg.

Abstract:

Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this proteins C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

Keywords: peripherin/rds, tetraspanin, intrinsically disordered, natively unstructured, photoreceptor, outer segment

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Article Details

VOLUME: 12
ISSUE: 7
Page: [677 - 686]
Pages: 10
DOI: 10.2174/0929866054696217
Price: $58