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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 12
ISSUE: 7
DOI: 10.2174/0929866054696217      Price:  $58









Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

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Author(s): L. M. Ritter, T. Arakawa and A. F.X. Goldberg
Pages 677-686 (10)
Abstract:
Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this proteins C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.
Keywords:
peripherin/rds, tetraspanin, intrinsically disordered, natively unstructured, photoreceptor, outer segment
Affiliation:
Eye Research Institute,Oakland University, 417 Dodge Hall, Rochester, MI 48309;