Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Author(s): S. Ponzi, C. Giuliano, M. Donghi, M. Poma, V. G. Matassa, I. Stansfield.

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 6 , 2005

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Abstract:

5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here we report the evolution and SAR of a series of 2-{2-[(arylsulfonyl)amino]phenyl analogues that show greater than 2 orders of magnitude improved activity over the original lead.

Keywords: hcv, ns5b polymerase, inhibitors, phenyldihydroxypyrimidines, sulfonamides

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Article Details

VOLUME: 2
ISSUE: 6
Year: 2005
Page: [456 - 461]
Pages: 6
DOI: 10.2174/1570180054771527
Price: $58