Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Author(s): Yulin Ren, Yawei Zhou, Xiaozhuo Chen, Yunhua Ye.

Abstract:

We reported that the extract of Mulgedium tatarica DC. exhibits anticancer activity. With the help of a tumor cell killing bioassay, the sesquiterpene lactones lactucopicrin (1), 11,13β-dihydrolactucopicrin (2), lactucin (3) and 11,13β-dihydrolactucin (4) were isolated and identified from this medicinal herb. SAR studies indicate that the ester group at position 8 and the exocyclic methylene group at position 11 play a major role in anticancer activities of lactucin-like guaianolides, a kind of sesquiterpene lactone.

Keywords: sesquiterpene lactone, guaianolides, mulgedium tatarica, anticancer activity, kb cells, bel 7402 cells

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Article Details

VOLUME: 2
ISSUE: 6
Year: 2005
Page: [444 - 450]
Pages: 7
DOI: 10.2174/1570180054771581
Price: $58