Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics

Author(s): George G. Harrigan , Daniel J. Brackett , Laszlo G. Boros .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 1 , 2005

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Abstract:

Comprehensive analysis of the metabolome can contribute to mechanism of action studies for small molecules discovered in phenotypic screens. Examples are presented in this overview of the rapidly developing field of “metabolic profiling.” These examples include the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-γ agonists, applications of Fourier-transform MS and the use of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.

Keywords: chemical genetics, reverse pharmacology, metabolic profiling, metabolic fingerprinting, metabonomics, metabolomics, sidmap

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2005
Page: [13 - 20]
Pages: 8
DOI: 10.2174/1389557053402800

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