Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues

Author(s): W.- S. Fang, X.- T. Liang.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 1 , 2005

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Abstract:

Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward “normal” and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.

Keywords: anticancer drugs, paclitaxel, structure-activity relationship (sar), multi-drug resistance (mdr), prodrugs, microtubule, pharmacophore

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2005
Page: [1 - 12]
Pages: 12
DOI: 10.2174/1389557053402837

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