Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

Author(s): Olaf Jahn, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart, Joachim Spiess.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 10 , 2005

Abstract:

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Keywords: corticotropin-releasing factor (crf), crf binding protein (crfbp), crfbp inhibitor, urocortin, cognitive deficits

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Article Details

VOLUME: 5
ISSUE: 10
Year: 2005
Page: [953 - 960]
Pages: 8
DOI: 10.2174/138955705774329500
Price: $58

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