Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?
Olaf Jahn, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart and Joachim Spiess
Pages 953-960 (8)
The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
corticotropin-releasing factor (crf), crf binding protein (crfbp), crfbp inhibitor, urocortin, cognitive deficits
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine,Hermann-Rein-Str. 3, 37075 Goettingen, Germany.