Effects of Subhypothermia on Ca2+, Mg2+, Excitatory Amino Acids and Plasma Endothelin in Brain Tissues of Mice with Acute Cerebral Infarction

Author(s): Z. C. Liu, F. Wen, C. Y. Li, S. G. Zhang, S. P. Mao.

Journal Name: Vascular Disease Prevention

Volume 4 , Issue 4 , 2007

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Abstract:

The increased content of calcium (Ca2+), excitatory amino acids (EAA) and endothelin (ET) as well as the decreased magnesium (Mg2+) in brain tissue with acute cerebral infarction will aggravate local damage. We measured the changes in Ca2+, EAA, ET and Mg2+in brain tissues of mice after acute cerebral infarction to assess the protective effects of subhypothermia. A total of 48 SD mice were randomly divided into a subhypothermia group and a control group; each was divided into 4 subgroups (6 mice in each). An improved thread embolism method was used as a middle cerebral artery infracted model. Subhypothermia was only administered to the treatment group. Mice were killed 1, 2, 4 and 8 h after infarction. The content of Ca2+, EAA and ET in ischemic brain tissues increased with the duration of ischemic time and the concentration of Mg2+fell in the control group. Compared with the control group, there was a significant difference in these changes in the subhypothermia group (P < 0.01). Subhypothermia can significantly inhibit the increase of harmful factors such as Ca2+, EAA and ET in ischemic brain tissues of experimental animals and the decrease of the protective Mg2+.

Keywords: Subhypothermia, calcium, magnesium, excitatory amino acids, endothelin, acute cerebral infarction

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [303 - 305]
Pages: 3
DOI: 10.2174/1567270010704040303
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