The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimers Disease

Author(s): K. Irie , K. Murakami , Y. Masuda , A. Morimoto , H. Ohigashi , H. Hara , R. Ohashi , K. Takegoshi , H. Fukuda , M. Nagao , T. Shimizu , T. Shirasawa .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 10 , 2007

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Abstract:

Senile plaques in the brain of patients with Alzheimers disease mainly consist of aggregates of amyloid β peptides (Aβ42, Aβ40). Aβ42 is more neurotoxic than Aβ40. This review describes recent findings from a structural analysis of Aβ42 aggregates and discusses their relevance to neurotoxicity through the formation of radicals.

Keywords: Alzheimer's disease, amyloidβ, cerebral amyloid angiopathy, ESR, neurotoxicity, proline, oxidative stress, solidstate NMR

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Article Details

VOLUME: 7
ISSUE: 10
Year: 2007
Page: [1001 - 1008]
Pages: 8
DOI: 10.2174/138955707782110187
Price: $58

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