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The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimers Disease

Author(s): K. Irie, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa.

Abstract:

Senile plaques in the brain of patients with Alzheimers disease mainly consist of aggregates of amyloid β peptides (Aβ42, Aβ40). Aβ42 is more neurotoxic than Aβ40. This review describes recent findings from a structural analysis of Aβ42 aggregates and discusses their relevance to neurotoxicity through the formation of radicals.

Keywords: Alzheimer's disease, amyloidβ, cerebral amyloid angiopathy, ESR, neurotoxicity, proline, oxidative stress, solidstate NMR

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Article Details

VOLUME: 7
ISSUE: 10
Year: 2007
Page: [1001 - 1008]
Pages: 8
DOI: 10.2174/138955707782110187
Price: $58