Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas

Author(s): James R. Van Brocklyn.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 10 , 2007

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Abstract:

Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.

Keywords: Glioma, glioblastoma multiforme, sphingolipids, sphingosine-1-phosphate, ceramide

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Article Details

VOLUME: 7
ISSUE: 10
Year: 2007
Page: [984 - 990]
Pages: 7
DOI: 10.2174/138955707782110123
Price: $58

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