The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

Title: The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

Volume: 4 Issue: 7

Author(s): Helio Gauze Bonacorso, Adriana Ferla, Cleber Andre Cechinel, Nilo Zanatta and Marcos Antonio Pinto Martins

Affiliation:

Keywords: Aminopyrimidines, pyrimidinones, deprotection, haloform reaction, ketones, heterocycles

Abstract: The one-step synthesis of a new series of protected 6-alkyl- and 6-aryl-2-acetylamino-4(3H)-pyrimidinones, where alkyl = CH3; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh and 4-OCH3Ph from the reaction of 4-methoxy-1,1,1- trichloroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile as solvent is reported. The acetylamino group of 2- acetylamino-4(3H)-pyrimidinones has also been hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidinones.

Cite this article as:

Bonacorso Gauze Helio, Ferla Adriana, Cechinel Andre Cleber, Zanatta Nilo and Pinto Martins Antonio Marcos, The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones, Letters in Organic Chemistry 2007; 4 (7) . https://dx.doi.org/10.2174/157017807782006335