The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

Author(s): Helio Gauze Bonacorso, Adriana Ferla, Cleber Andre Cechinel, Nilo Zanatta, Marcos Antonio Pinto Martins.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 7 , 2007


The one-step synthesis of a new series of protected 6-alkyl- and 6-aryl-2-acetylamino-4(3H)-pyrimidinones, where alkyl = CH3; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh and 4-OCH3Ph from the reaction of 4-methoxy-1,1,1- trichloroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile as solvent is reported. The acetylamino group of 2- acetylamino-4(3H)-pyrimidinones has also been hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidinones.

Keywords: Aminopyrimidines, pyrimidinones, deprotection, haloform reaction, ketones, heterocycles

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Article Details

Year: 2007
Page: [495 - 499]
Pages: 5
DOI: 10.2174/157017807782006335
Price: $58

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