The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery

Author(s): Moniola S. Olusanjo, Sabbir Ahmed.

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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Abstract:

The approximate representation of the active site of the type 3 isozyme of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD3) has been derived from the consideration of the proposed mechanism for the reduction reaction. Using the transition-state (TS), the mode of action of a number of inhibitors has been rationalised.

Keywords: Type 3, Isozyme, 17β-Hydroxysteroid dehydrogenase, 17β-HSD3, Transition-state, Reduction reaction

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [527 - 531]
Pages: 5
DOI: 10.2174/157018007781788525
Price: $58

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