Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum

Author(s): Francoise Debierre-Grockiego, Jorg Schmidt, Eliezer Flescher, Ralph T. Schwarz.

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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Abstract:

Artemisinin induces the growth inhibition of Plasmodium falciparum by sphingomyelinase-generated ceramide. To understand whether artemisinin could have another effect, sphingolipid biosynthesis was studied. Our result shows that a delay in the formation of final products (globoside, cerebrosides) production might be involved in the increase of ceramide.

Keywords: Plasmodium, Artemisinin, Serine, Ceramide, Sphingomyelin

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [524 - 526]
Pages: 3
DOI: 10.2174/157018007781788499
Price: $58