Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum
Ralph T. Schwarz.
Artemisinin induces the growth inhibition of Plasmodium falciparum by sphingomyelinase-generated ceramide. To understand whether artemisinin could have another effect, sphingolipid biosynthesis was studied. Our result shows that a delay in the formation of final products (globoside, cerebrosides) production might be involved in the increase of ceramide.
Keywords: Plasmodium, Artemisinin, Serine, Ceramide, Sphingomyelin
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