First In Vivo Evaluation of a New Morpholine Analog

Author(s): M. Altamura, A. Guidi, F. Pasqui, M. Tramontana, K. Worm-Leonhard.

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.

Keywords: Tachykinins, Neurokinin A, 6,8-dioxa-3-aza-bicyclo(3.2.1)octane, Morpholine, Oligomer

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Article Details

Year: 2007
Page: [520 - 523]
Pages: 4
DOI: 10.2174/157018007781788534
Price: $58

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